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"For nearly a century, researchers have strained to hear the whispering conversation of cells, hoping to master the basics of their language. In place of words, cells use chemicals, linking molecule to molecule to construct sentences that obey formal rules of grammar and syntax as those that govern our own spoken language."
--Debra Niehoff, Ph.D, Neurobiologist at Johns Hopkins University School of Medicine.
Perfector nano-science introduces proprietary waveforms at the nano-ampere range that resonate with the intricate language of cellular, bio-electrical impulses to regenerate tissue, balance and sculpt the face.
"Improved technology will reveal a whole microcosmos of electrical signals in a multitude of electrically and chemically excitable cell types."
--Edwin Neher, MD, Nobel Prize Winner (Nobel Lecture, 1991)
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Summary Historical Account of Micro and Macro - Electrical Stimulation
by Mel C Siff PhD
Macro-current Stimulation (currents over about 1 milliamp)
Micro-current Stimulation (currents below about 1 milliamp)
American interest in electrostimulation as a training adjunct was aroused in 1971, when Kots in Russia reported increases of more than 20% in muscle strength, speed and power produced by several weeks of electrotraining. Unable to produce comparable results, the Canadians invited him to lecture at Concordia University in 1977
Applications of Macrocurrent Stimulation
A literature review reveals the following major uses of macrocurrent stimulation.
- Increase in muscle strength
- Re-education of muscle action
- Facilitation of muscle contraction in dysfunctional or unused muscle
- Increase of muscular and general endurance
- Increase in speed of muscle contraction
- Increase in local blood supply
- Provision of massage
- Relief of pain
- Reduction of muscle spasm
- Promotion of relaxation and recuperation
- Increase in range of movement
- Reduction of swelling
- Reduction of musculoskeletal abnormalities
- Preferential recruitment of specific muscle groups
- Acute increase in strength
- Improvement in metabolic efficiency
The Emergence of micro-current Stimulation
Recent research and clinical experience have revealed that electric currents as much as 1000 times smaller than that of all the traditional physical therapy modalities can be far more successful than the latter in achieving many of the benefits outlined in the previous section.
Currents as low as 10 microamps (millionths of an amp) pulsating at between 0.1 to 400Hz are too weak to cause muscle contraction, block pain signals or cause local heating, yet their effectiveness and safety is often superior in many applications to that of faradism, interferentialism and conventional TENS (Matteson & Eberhardt, 1985). Cellular and subcellular processes not involving cell discharge, propagated electrical impulses, or muscle contraction, appear to be involved with cellular growth and repair.
Some studies have produced findings which offer partial answers to the questions posed by microstimulation. For instance, work by Becker and others suggests that small, steady or slowly varying currents can cause sub-threshold modulation of the electric fields across nerve and glial cells, thereby directly regulating cell growth and communication (Becker, 1974; Becker & Marino, 1982). In this respect, some of Becker's applications included the acceleration of wound healing, partial regeneration of amphibian and rat limbs, and induction of narcosis with transcranial currents. Nordenström maintains that these electric currents can stimulate the flow of ions along the blood vessels and through the cell membranes which constitute the body's closed electric circuits postulated by his theory (Nordenström, 1983).
Pilla (1974) has paid particular attention to electrochemical information transfer across cell membranes. The model in this case hypothesizes that the molecular structure of the cell membrane reflects its current genetic activity. Here, the function of a cell at any instant is determined by feedback between DNA in the cell nucleus and a macromolecule inducer liberated from the membrane by means of a protein (enzyme) regulator derived from messenger RNA activity within the cell. The activity of these membrane-bound proteins is strongly modulated by changes in the concentration of divalent ions (such as calcium Ca++) absorbed on the membrane. ES may elicit these ionic changes and thereby modify cell function.
It has been shown that ES at 5Hz stimulates synthesis of DNA in chick cartilage cells and rat bone by as much as 27%, but not in chick skin fibroblasts or rat spleen lymphocytes (Rodan et al, 1978). Not only does the effect of ES appear to be tissue-specific, but the increase in DNA synthesis occurs 4-6 hours after 15 minutes of ES. The process of membrane depolarisation carried by sodium ions seems to be followed by an increase in intracellular Ca++ concentration, thereby triggering DNA synthesis in cells susceptible to the particular stimulus. Further work by Pilla (1981) has confirmed the existence of cellular 'windows' which open most effectively to certain frequencies, pulse widths and pulse amplitudes. To attune the ES signal to these parameters, monitoring of tissue impedances is preferable, a system employed by so-called 'Intelligent TENS' devices.
In addition, Cheng et al (1982) have shown that stimulation with currents from 50-1000 microamps can increase tissue ATP concentrations in rats by 300-500%, and enhances amino acid transport through the cell membrane and consequent protein synthesis by as much as 40%. Interestingly, the same study reported that increasing the current above only one milliamp was sufficient to depress tissue ATP and protein synthesis - and traditional ES most commonly applies currents exceeding 20 milliamps, at which stage this depression being nearly 50%.
Micro-current stimulation (MICS - currents below one milliamp), does not act as a stressor. Instead, the evidence implies that it elicits biochemical changes associated with enhanced adaptation, growth and repair. Since MICS appears to operate more on the basis of resonant attunement of the stimulus to cellular and subcellular processes, the specific therapeutic effects are determined by how efficiently the stimulation parameters match the electrical characteristic of the different cells, in particular, their impedance at different frequencies. MICS may be applied in several ways to facilitate restoration:
- locally over specific soft tissues
- transcranially via electrodes on the earlobes or on sites on the surface of the skull
- at acupuncture points on the body, hands or ears.
It is generally entirely safe to apply MICS anywhere on the body, because the current and energy transmitted is too low to produce any thermal or electrolytic effects on vital tissues. Under no circumstances should MACS be applied across the brain, as it can cause serious harm. It is generally not advisable to apply any form of ES to epileptics, pregnant women, cardiac patients or persons with heart pacemakers.
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